Genetics
Jul 6, 2023

Biological age and the importance of weight control in attenuating it

“The potential significance of weight control and the treatment of overweight in combating accelerated aging needs to be emphasised.”

Biological age and the importance of weight control in attenuating it

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Key findings:

  • Our genetics do not change over a lifespan; but our epigenetics are modified by your lifestyle and other environment factors.
  • The most studied epigenetic phenomenon is called “DNA methylation”. It works like a switch to turn on and off the gene expression. Even if two individuals have the same genotype, depending on their epigenetic profile, the gene can express differentially.
  • Scientists invented the “epigenetic clocks” to measure one’s biological age using the DNA methylation phenomenon. These “clocks” can measure how biologically old you are, as opposed to your chronological age (“how many years you have lived”).
  • A recent study by Chen Z et al found that certain genetic drivers, such as being overweight, are significantly associated with aging; thus, weight control is very important in delaying biological aging.

 Find out more:

  • MyDigitalTwin’s primary goal is to help customers achieve healthy aging. In that regard, we provide a total lifestyle solution designed to help you reach your health goals that ultimately leads to “healthy aging”.
  • Currently, MyDigitalTwin is working to include the genetic variants related to biological age.

Sources:

Chen, Z., Chen, Z., & Jin, X. (2023). Mendelian randomisation supports causality between overweight status and accelerated aging. Aging Cell, 00, e13899. https://doi.org/10.1111/acel.13899

Chen, R, Wang, Y, Zhang, S, et al. Biomarkers of ageing: Current state-of-art, challenges, and opportunities. MedComm – Future Med. 2023; 2:e50. doi:10.1002/mef2.50

Featured photo by Jon Tyson on Unsplash

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